U = Universally Loved/hated/despised. What box do your characters fit in to here and why? Is the judgement against them correct or not? How do your characters handle being universally loved/hated/despised and have any of them managed to go from one category to another? (I can see stories in a loved character doing something stupid and ending up being despised for it, to name one example).
V = Victim. Is your character a victim? I'm not just referring to the crime or horror genres here. Regardless of genre, you can come up with characters who are victims or show the attitude which means they are likely to become victims. Are they self-pitying or do they fight the urge to "be a victim"?
W = Witty and Wise? Two "W's" for the price of one here! Do your characters fall into these categories? Are they loved or hated for it? How did they develop wisdom - was it by listening to others, learning from their own mistakes or both?